An unprecedented pandemic in 2020 brought Howard Brown Health’s mission into focus. Amidst a backdrop of uncertainty, COVID-19 created an immediate crisis requiring a coordinated response in the service of public health and for the safety of historically under-resourced communities. With a bench of experts in community health, infectious disease, epidemiology, and contact tracing, Howard Brown quickly responded with testing stations, innovative partnerships, and revised protocols to keep patients and staff safe from a previously unknown virus. Using experience in crisis HIV response, social service support, and wraparound medical care, Howard Brown is uniquely positioned to adapt to urgent needs during an unpredictable time.