Anal cancer incidence has been increasing for several years and disproportionality impacts people living with HIV; people with a history of cancer of the cervix, vagina, or vulva; people who have receptive anal intercourse or play with multiple partners; and people who have chronic HPV. The screening, early detection, and treatment of anal dysplasia and anal cancer has the potential to significantly improve morbidity and mortality as early detection can facilitate a cure. In response to this, Howard Brown has developed screening guidelines as a tool to identify patients who are more likely to benefit from anal dysplasia screening using the best available evidence.